The Binding Interface Database is no longer maintained. All new information should be submitted to the wikiBID. All correspondence should be sent to Jerry Tsai.

Overview:

 

     An overflow of information on the characterization of protein-protein interactions at the amino-acid level is continuing to develop with the goal of better understanding protein interfaces. For this reason it is necessary to acquire a protein-protein interaction database in which an enormous number of interactions can be easily accessed.

 

     The Binding Interface Database (BID) is structured to organize vast amounts of protein interaction information into tabular form, graphical contact maps, and descriptive functional profiles. Detailed protein descriptions, interaction descriptions, bond formation, and the strength of each amino acid's contribution to binding were systematically obtained by mining the primary literature containing alanine scanning and site-directed mutations.

 

BID Status:

There are currently interacting protein pairs with over hot spots documented. System that have been searched and entered include: Calmodulin (CAM) interacting proteins, Mitogen activated protein kinase (MAPK) signaling proteins, Wnt pathway, BMP/TGF pathway, Jak/STAT, Chaperones and chaperonins, Antigen/Antibody interactions, Cell Adhesion and Junction molecules, Growth Factors, Blood coagulation pathway, Apoptosis pathway, tumor suppressors and various other proteins.